| 20-GATE | 1961 | ↓⊕Internal Translators | ↓⊕United States | GATE for the G-20 |
| 90-PAC | 1961 | ↓⊕Report Generators | ↓⊕United States | Report generation package for the IBM 7090 |
| ACE | 1961 | ↓⊕Early Autocodes | ↓⊕United Kingdom | Autocode for the ACE |
| ACT III | 1961 | ↓⊕Generalised programming | ↓⊕United States | Machine independent language |
| ADAPT | 1961 | ↓⊕Numerical Control | ↓⊕United States | Subset of APT |
| Aerojet Commercial NELIAC | 1961 | | ↓⊕United States | Extension to NELIAC for commercial computing |
| ALABOL | 1961 | ↓⊕COBOL-60 | ↓⊕United States | Hybrid of COBOL and ALGOL |
| ALCOR | 1961 | ↓⊕True ALGOL60s | ↓⊕International | ALCOR-Gruppe ALGOL |
| ALGY | 1961 | ↓⊕Algebraic | ↓⊕United States | Formula manipulation language |
| ALPHA | 1961 | ↓⊕True ALGOL60s | ↓⊕Russian Federation | Russian rich maths extension of Algol 60 |
| APACHE | 1961 | ↓⊕Analog | ↓⊕Italy | Analog simulation language |
| APT III | 1961 | ↓⊕Numerical Control | ↓⊕United States | Automatically Programmed Tools v3 |
| AUTOCODER Decision Table Assembler | 1961 | ↓⊕Decision tables | ↓⊕United States | Decision table structures for 7070 |
| BASEBALL | 1961 | ↓⊕Ad hoc query languages | ↓⊕United States | Constrained natural language for querying attribute value pairs |
| BEEF | 1961 | ↓⊕Fortran I-III Coeval | ↓⊕United States | Business and Engineering Enriched FORTRAN |
| BETA | 1961 | ↓⊕True ALGOL60s | ↓⊕Russian Federation | Russian List processing ALGOL |
| BLODI | 1961 | ↓⊕Expression oriented | ↓⊕United States | BLOck DIagram |
| BMD | 1961 | ↓⊕Statistical | ↓⊕United States | Bio-Medical statistical language |
| Case ALGOL | 1961 | ↓⊕True ALGOL60s | ↓⊕United States | ALGOL 60 from Case |
| CERN Autocode | 1961 | ↓⊕Early Autocodes | ↓⊕Switzerland | Autocode for IBM 709 |
| CL-II | 1961 | ↓⊕Grammar and Syntax-oriented | ↓⊕United States | Compiler generator language |
| COBOL Narrator 61 | 1961 | ↓⊕COBOL-61 | ↓⊕United States | RCA Cobol 61 |
| COBOL Narrator EE | 1961 | ↓⊕COBOL-60 | ↓⊕United Kingdom | English Electric version of RCA COBOL |
| COBOL-61 | 1961 | ↓⊕COBOL-61 | ↓⊕United States | First revision of CODASYL COBOL |
| Codematic | 1961 | ↓⊕Chemical formula languages | ↓⊕United States | Cosmetics language |
| COGO | 1961 | ↓⊕2d shape | ↓⊕United States | CO-ordinate GeOmetry system |
| Compact COBOL | 1961 | ↓⊕COBOL-60 | ↓⊕United States | Standard subset of COBOL |
| COMPASS | 1961 | ↓⊕Symbolic assemblers | ↓⊕United States | |
| CTSS | 1961 | ↓⊕Command systems | ↓⊕United States | Command language for CTSS |
| Culler-Fried System | 1961 | ↓⊕Arithmetic | ↓⊕United States | Interactive mathematics environment |
| DASK Algol | 1961 | ↓⊕True ALGOL60s | ↓⊕Denmark | Danish ALGOL |
| Dracula | 1961 | ↓⊕Symbolic assemblers | ↓⊕United States | CCC Symbolic assembler |
| DYSAC | 1961 | ↓⊕Difference Equations | ↓⊕United States | Continuous simulation system |
| ECONOMIST | 1961 | ↓⊕Moscow languages | ↓⊕Russian Federation | Minsk-1 Commercial Autocoder |
| Elliot Mark II AUTOCODE | 1961 | ↓⊕Early Autocodes | ↓⊕United Kingdom | Version II of the Elliot Autocode |
| EMIDEC Algol | 1961 | ↓⊕True ALGOL60s | ↓⊕United Kingdom | |
| ENGINEER | 1961 | ↓⊕Moscow languages | ↓⊕Russian Federation | Minsk-1 Engineering Autocoder |
| ETF | 1961 | ↓⊕Ad hoc query languages | ↓⊕United States | Early query language |
| FIELDCOM | 1961 | | ↓⊕United States | |
| FRINGE | 1961 | ↓⊕Report Generators | ↓⊕United States | Report writer for GECOM |
| GASP | 1961 | ↓⊕Event scheduling | ↓⊕United States | General Activity Simulation Program |
| GENIE | 1961 | ↓⊕True ALGOL60s | ↓⊕United States | Algorithmic language for the Rice R1 |
| Geometrical machine language | 1961 | ↓⊕Numerical Control | ↓⊕Russian Federation | |
| GIRLS | 1961 | ↓⊕Ad hoc query languages | ↓⊕United States | Generalized Information Retrieval and Listing System |
| GOGOL | 1961 | ↓⊕Other Algol 60s | ↓⊕United States | PDP-1 Algol 60 |
| GOM | 1961 | ↓⊕Other IAL Coeval | ↓⊕United States | |
| Grasselli and McCluskey ALGOL | 1961 | ↓⊕Linear | ↓⊕United States | ALGOL modified for programming logical problems |
| HARTRAN | 1961 | ↓⊕Fortran I-III Variants | ↓⊕United Kingdom | Harwell FORTRAN |
| ICES | 1961 | ↓⊕Civil | ↓⊕United States | Integrated Civil Engineering System |
| Input | 1961 | ↓⊕True ALGOL60s | ↓⊕Russian Federation | Russian algorithmic language |
| Lakhmi synthetic language for biology | 1961 | ↓⊕Individual | ↓⊕Russian Federation | Biological simulations |
| Legal Retrieval | 1961 | ↓⊕Ad hoc query languages | ↓⊕United States | Information retrieval system for legal documents |
| LEO Intercode | 1961 | ↓⊕Other DPLs | ↓⊕United Kingdom | Intercode for LEO III |
| Leviathan | 1961 | ↓⊕Systems | ↓⊕United States | Behavioural systems language |
| L-hat | 1961 | ↓⊕Information algebra | ↓⊕United States | SHARE Information Algebra |
| Lincos | 1961 | ↓⊕Symbolic | ↓⊕Netherlands | Language for cosmic intercourse |
| LP 3 | 1961 | | | |
| LP/90 | 1961 | ↓⊕Optimisation and LP | ↓⊕United Kingdom | Linear Programming 90 |
| LP/94 | 1961 | | ↓⊕United Kingdom | |
| MADCAP II | 1961 | ↓⊕Multiline | ↓⊕United States | Second version of MADCAP |
| MADCAP III | 1961 | ↓⊕Multiline | ↓⊕United States | Version 3 of Madcap |
| MATRAN | 1961 | ↓⊕Optimisation and LP | ↓⊕United States | Linear Programming Language |
| McGee Information Algebra | 1961 | ↓⊕Other DPLs | ↓⊕United States | McGee |
| Mem-theory | 1961 | ↓⊕Generalised programming | ↓⊕United States | Graph-based universal language |
| Minuteman | 1961 | ↓⊕Ad hoc query languages | ↓⊕United States | GEC information retrieval system |
| MOD IV | 1961 | ↓⊕Expression oriented | ↓⊕United States | Digital differential analyzer simulator |
| NEAT COBOL | 1961 | ↓⊕COBOL-60 | ↓⊕United States | NCR COBOL compiler |
| NUCOM | 1961 | ↓⊕Numerical Control | ↓⊕United States | CNC language |
| Oak Ridge ALGOL compiler | 1961 | ↓⊕True ALGOL60s | ↓⊕United States | Algol compiler for CDC 1604 |
| Oettinger's shape language | 1961 | | ↓⊕United States | |
| PAC | 1961 | | ↓⊕United States | Visual programming system for ACSI-Matic |
| PERT | 1961 | ↓⊕Generalised programming | ↓⊕United States | McBee Royal general coding system |
| PROGENY | 1961 | ↓⊕Report Generators | ↓⊕United States | UNIVAC report generator |
| PSK-l | 1961 | ↓⊕Moscow languages | ↓⊕Russian Federation | Russian multi-purpose compiling system |
| Rabinow EDP Language | 1961 | | ↓⊕United States | |
| Required-COBOL | 1961 | ↓⊕COBOL-60 | ↓⊕United States | Minimal Cobol 60 subset |
| ROAR | 1961 | ↓⊕Symbolic assemblers | ↓⊕United States | RPC-400 Assembler |
| ROHR Numerical Tool Control | 1961 | ↓⊕Numerical Control | ↓⊕United States | Sperry Rand NC |
| RPG/360 | 1961 | ↓⊕Report Generators | ↓⊕United States | RPG for the IBM 360 |
| S1 | 1961 | ↓⊕Fortran I-III Variants | ↓⊕United Kingdom | Harwell FORTRAN II |
| S4 | 1961 | ↓⊕Symbolic assemblers | ↓⊕United States | UNIVAC Assembler |
| SAINT | 1961 | ↓⊕Algebraic | ↓⊕United States | A program to do formal integration |
| SCL | 1961 | ↓⊕Statistical | ↓⊕United States | IBM statistical programming language |
| SCRAPS | 1961 | ↓⊕Generalised programming | ↓⊕United States | Signal Corps autocode |
| SEAL | 1961 | ↓⊕COBOL coeval | ↓⊕United Kingdom | Business relative language |
| SIMSCRIPT | 1961 | ↓⊕Event scheduling | ↓⊕United States | Discrete simulations package |
| SIRIUS Autocode | 1961 | ↓⊕Early Autocodes | ↓⊕United Kingdom | Autocode for the Ferranti Sirus |
| SMALGOL | 1961 | ↓⊕True ALGOL60s | ↓⊕United States | |
| SMALGOL-61 | 1961 | ↓⊕True ALGOL60s | ↓⊕United States | |
| SOAP 2L | 1961 | ↓⊕Symbolic assemblers | ↓⊕United States | Improved SOAP |
| STRAP II | 1961 | ↓⊕Symbolic assemblers | ↓⊕United States | STRetch Assembly Program |
| STRIP | 1961 | ↓⊕Scanning and section control | ↓⊕United States | NBS image manipulation system |
| Tabular descriptive language | 1961 | ↓⊕Decision tables | ↓⊕United States | IBM decision table language |
| Task | 1961 | ↓⊕Information algebra | ↓⊕United States | Gorn generalised data system |
| THAT | 1961 | ↓⊕Symbolic assemblers | ↓⊕United States | Assembler at IT, replacement for SOAP and TASS |
| Uspensky information processing language | 1961 | ↓⊕Information algebra | ↓⊕Russian Federation | |
| X1 Algol 60 | 1961 | ↓⊕True ALGOL60s | ↓⊕Netherlands | |
| Z22 compiler | 1961 | ↓⊕Macroassemblers | ↓⊕Germany | High level macro compiler for Zuse Z22 |