| 9AP | 1959 | ↓⊕Macros | ↓⊕United States | Assembler autocode for the 709/0 |
| A9 | 1959 | ↓⊕Low-level Autocoders | ↓⊕Australia | Interpreter for SILLIAC |
| ACOMCAS | 1959 | ↓⊕Low-level Autocoders | ↓⊕United States | Autocoder for UNIVAC |
| ACSI-Matic | 1959 | ↓⊕COBOL coeval | ↓⊕United States | Associative query language |
| ALGOL 60 | 1959 | ↓⊕True ALGOL60s | ↓⊕International | Algorithm Language |
| Algol 60 Publishing | 1959 | ↓⊕True ALGOL60s | ↓⊕International | Typographically rich form of Algol 60 |
| Alphacode | 1959 | ↓⊕Early Autocodes | ↓⊕United Kingdom | High level autocode for English Electric Deuce |
| ALTAC | 1959 | ↓⊕Fortran I-III Variants | ↓⊕United States | Algorithms on TAC |
| ANCP | 1959 | ↓⊕Autocode Coeval | ↓⊕United States | Datatron autocode |
| APG-1 | 1959 | ↓⊕Other DPLs | ↓⊕United States | Dupont business oriented language |
| APL | 1959 | ↓⊕Generalised programming | ↓⊕United States | Automatic Programming Language |
| APX III | 1959 | ↓⊕Low-level Autocoders | ↓⊕United States | Datatron autocode |
| AS Intercode | 1959 | ↓⊕Early Autocodes | ↓⊕United Kingdom | Port of Intercode to run at Armstrong Siddley |
| BASIC AUTOCODER | 1959 | ↓⊕Low-level Autocoders | ↓⊕United States | Simplified AUTOCODER |
| Bell SAP | 1959 | ↓⊕Macroassemblers | ↓⊕United States | SAP with conditional and recursive macros |
| BNF | 1959 | ↓⊕Grammar and Syntax-oriented | ↓⊕United States | Backus Naur Form |
| Calculus | 1959 | ↓⊕Fortran I-III Coeval | ↓⊕United States | Compiler at CASE |
| CAP | 1959 | ↓⊕Symbolic assemblers | ↓⊕United States | Cornell Assembler |
| CODEL | 1959 | ↓⊕Early Autocodes | ↓⊕United Kingdom | Autocoder from ICT |
| Commercial Translator | 1959 | ↓⊕COBOL coeval | ↓⊕United States | |
| D-0 | 1959 | ↓⊕COBOL coeval | ↓⊕United States | |
| DAISY 201 | 1959 | ↓⊕Low-level Autocoders | ↓⊕United States | G-15 Autocoder |
| DART | 1959 | ↓⊕Strict Early Fortrans | ↓⊕United States | Simplified FORTRAN + brackets |
| DEPI 4 | 1959 | ↓⊕Differential Equations | ↓⊕United States | Continuous simulation language |
| DOW COMPILER | 1959 | ↓⊕Low-level Autocoders | ↓⊕United States | Dow Chemicals Autocoder |
| DYNAMO | 1959 | ↓⊕Expression oriented | ↓⊕United States | DYNAmic MOdels simulation |
| ERFPI | 1959 | | ↓⊕United States | |
| FAP | 1959 | ↓⊕Symbolic assemblers | ↓⊕United States | FORTRAN Assembly Program |
| FAST | 1959 | ↓⊕Fortran I-III Variants | ↓⊕United States | FORTRAN compiler |
| FLIP | 1959 | ↓⊕List | ↓⊕Australia | Functional list processor |
| FORTRUNCIBLE | 1959 | ↓⊕Autocode Coeval | ↓⊕United States | FORTRAN/RUNCIBLE |
| GAT | 1959 | ↓⊕Internal Translators | ↓⊕United States | Generalized Algebraic Translator |
| GEPURS | 1959 | ↓⊕Low-level Autocoders | ↓⊕United States | General purpose autocoder |
| Gordon Simulator | 1959 | ↓⊕Activity scanning | ↓⊕United States | Systems simulation dialect of FORTRAN |
| GPSS | 1959 | ↓⊕Event scheduling | ↓⊕United States | General Purpose Systems Simulator |
| HAYSTAQ | 1959 | ↓⊕Ad hoc query languages | ↓⊕United States | Restricted input querying language |
| Ingerman generalised BNF | 1959 | | ↓⊕United States | |
| INTERCOM 1000 | 1959 | ↓⊕Low-level Autocoders | ↓⊕United States | Autocode for the Bendix G-15 |
| Intrinsic | 1959 | | ↓⊕United Kingdom | |
| JAZ | 1959 | ↓⊕Low-level Autocoders | ↓⊕United States | Autocode for Royal McBee |
| JOVIAL | 1959 | ↓⊕Jovials | ↓⊕United States | Airforce International Algebraic Language |
| Kanner algebraic translator | 1959 | ↓⊕Fortran I-III Coeval | ↓⊕United States | Algebraic translation system |
| KISS | 1959 | ↓⊕High-level Autocoders | ↓⊕United States | Chrysler 650 Autocode |
| Linear lisp | 1959 | ↓⊕Lazy Evaluation LISPs | ↓⊕United States | |
| LISP 1.5 | 1959 | ↓⊕Lazy Evaluation LISPs | ↓⊕United States | LISP major release |
| LT-2 | 1959 | ↓⊕Linear | ↓⊕United States | |
| Macro SAP | 1959 | ↓⊕Macroassemblers | ↓⊕United States | Macro compiler modification of SAP |
| MAD | 1959 | | ↓⊕United States | Michigan Algorithm Decoder |
| Micro-flowcharts | 1959 | | | |
| MUSE | 1959 | ↓⊕High-level Autocoders | ↓⊕United States | Modified USE |
| N1 | 1959 | ↓⊕Other lambda | ↓⊕Italy | Olivetti's non-procedural language |
| Nugent IR language | 1959 | | | |
| ORBIT | 1959 | ↓⊕Internal Translators | ↓⊕United States | Oak Ridge IT |
| Pegasus AUTOCODE | 1959 | ↓⊕Early Autocodes | ↓⊕United Kingdom | Autocode for the Pegasus system |
| Pegasus function interpreter | 1959 | ↓⊕Algebraic | ↓⊕United Kingdom | Algebraic system for the Pegasus |
| Perlis and Evans multilevel system | 1959 | | | |
| POGO | 1959 | ↓⊕Low-level Autocoders | ↓⊕United States | G-15 Autocoder |
| Polynomial PRORAB | 1959 | ↓⊕Algebraic | ↓⊕Russian Federation | |
| Q-0 | 1959 | ↓⊕COBOL coeval | ↓⊕United States | |
| RPG | 1959 | ↓⊕Report Generators | ↓⊕United States | Report Program Generator |
| SALE | 1959 | ↓⊕Fortran I-III Coeval | ↓⊕United States | Algorithmic language for Engineers |
| SCAD | 1959 | ↓⊕Multiline | ↓⊕United States | Grems/Post document access language |
| Sequence Diagram Simulator | 1959 | ↓⊕Activity scanning | ↓⊕United States | Early diagramatic simulator |
| SHADOW II | 1959 | ↓⊕Grammar and Syntax-oriented | ↓⊕United States | Syntax-directed compiler |
| SHARE Information Algebra | 1959 | ↓⊕Other DPLs | ↓⊕United States | Description language for inhomogeneous collection of entities |
| SHELL | 1959 | ↓⊕Low-level Autocoders | ↓⊕United States | Datatronic autocoder |
| SIMCOM | 1959 | ↓⊕Process interaction | ↓⊕United States | Simulation compiler |
| SMASHT | 1959 | ↓⊕Macroassemblers | ↓⊕United States | SDC symbolic assembler |
| SOAP H | 1959 | ↓⊕Symbolic assemblers | ↓⊕United States | |
| SPAR | 1959 | ↓⊕Low-level Autocoders | ↓⊕United States | Autocoder for Burroughs/Datatron 200 series |
| SPEED | 1959 | ↓⊕Low-level Autocoders | ↓⊕United States | Autocode for LGP-30 |
| SPEEDEX | 1959 | ↓⊕Symbolic assemblers | ↓⊕United States | Assembler for 701 |
| Spool | 1959 | ↓⊕Autocode Coeval | ↓⊕United States | |
| SPUD | 1959 | ↓⊕Other Conversational | ↓⊕United States | Demonstration language |
| STAR I | 1959 | ↓⊕Symbolic assemblers | ↓⊕United States | Burroughs 220 assembler |
| STEVE | 1959 | ↓⊕Early Autocodes | ↓⊕United Kingdom | Symbolic language for the DEUCE |
| TAC | 1959 | ↓⊕Symbolic assemblers | ↓⊕United States | TRANSAC Assembler Compiler |
| TAP | 1959 | ↓⊕Symbolic assemblers | ↓⊕United States | TRANSAC symbolic assembler |
| TASS | 1959 | ↓⊕Symbolic assemblers | ↓⊕United States | Tech Assembly System |
| TASS I | 1959 | ↓⊕Autocode Coeval | ↓⊕United States | Autocoder for 650 |
| The Conversational Machine | 1959 | | ↓⊕United States | |
| THREADED LISTS | 1959 | ↓⊕List | ↓⊕United States | List-processing language |
| TRAC | 1959 | ↓⊕Macros | ↓⊕United States | A man-machine string manipulating language |
| TRAWL | 1959 | ↓⊕Lines | ↓⊕United States | Read and write sublanguage |
| TUFF/TUG | 1959 | | ↓⊕United States | |
| TUG Algol | 1959 | ↓⊕Other IAL Coeval | ↓⊕United States | TRANSAC IAL |
| Wegstein algebraic language | 1959 | ↓⊕Intermediate languages and VMs | ↓⊕United States | Intermediate language |
| X-6 | 1959 | ↓⊕Macroassemblers | ↓⊕United States | |